Ponazuril Dosage Calculator for Rabbits [Updated on: 09/1/24 07:00]

Please note this information is only for reference purposes only. Please see a rabbit savvy vet for the correct doseage and use for your rabbit's particular condition.

       Most have access to toltrazuril (Baycox, used as a anticoccidial medication) to treat coccidia in rabbits. The US does not have access to this product, but ponazuril (Marquis) is available and does just as well. Ponazuril (Marquis) is sold as a thick oral paste, in a large syringe (127 g, 15% w/w), to treat EPM in horses. Normally the paste is compounded (with distilled or sterile water) to achieve a concentration of 50 mg/mL when used with rabbits. Caution: Federal (U.S.A.) law restricts this drug to use by or on the order of a licensed veterinarian.

       Ponazuril is an active metabolite of toltrazuril (the alternate chemical name for ponazuril is toltrazuril sulfone). While they are very close chemically they should be treated (dosed) differently. Most likely the bioavailability is different. "The baycox [toltrazuril] is much more likely to cross a cell membrane on its own over ponazuril that has got a different structure. Thus you would need less of it have the same effect on the liver parasites."

       There are a number different treatment protocols currently for rabbits both with amounts and times given. Dr.H (HRS iHRS Center) recommends a 20 day dosing protocol (3 days on, 14 days off, 3 days on) dosing at 20 mg/kg with ponazuril for treatment. Dr.H & Dr.N's (CVC) prophylaxis protocol is 50 mg/kg, once. This is the protocol that the math is based on below. If you have any questions please talk to your rabbit-savvy vet! The calculator will only show the dosing based on the data inputted.
Calculate dosing
Dosage in mg/kg: mg/kg
Rabbit's weight kg lbs  kg

Enter values & click calculate ↵
50  mg/kg  ×  2.26  kg 50  mg/mL = 2.26   mL
Prophylaxis protocol
Once
Using a 50 mg/mL compound
Dose
2.26 mL [mls] PO [orally]

 

        Based on the numbers entered, your rabbit of 2.26 kg (4.98 lbs) would use a dose of 2.26 mL [mls] (2.26 cc), of ponazuril.

Math for a 2.26kg or 4.98lb rabbit: 50 mg/kg × 2.26 kg ÷ 50 mg/mL ≈ 2.26 mL

113 mg ÷ 4.98 lbs = 22.68 mg/lb ≈ 22.68 mg/lb



Twenty day dosing protocol
3 days on, 14 days off, 3 days on
Using a 50 mg/mL compound
Day Dose
1 2.26 mL [mls] PO [orally]
2 2.26 mL [mls] PO [orally]
3 2.26 mL [mls] PO [orally]
4 →17 0̸
18 2.26 mL [mls] PO [orally]
19 2.26 mL [mls] PO [orally]
20 2.26 mL [mls] PO [orally]

 

        Based on the numbers entered, your rabbit of 2.26 kg (4.98 lbs) would use a dose of 2.26 mL [mls] (2.26 cc), of ponazuril.

Math for a 2.26kg or 4.98lb rabbit: 50 mg/kg × 2.26 kg ÷ 50 mg/mL ≈ 2.26 mL

113 mg ÷ 4.98 lbs = 22.68 mg/lb ≈ 22.68 mg/lb



       Dr. Dana Krempels recommends "20mg/kg Q 24 hours" for ponazuril/Ponazuril. Her own data shows complete parasite eradication in three days of treatment with ponazuril (Marquis). 2007

Storage per the manufacturer for the original syringe applicator: 20-25°C (68-77°F), excursions permitted between 15-30°C (59-86°F). Do not allow product to come in contact with heat or exposure to sunlight.

"In gestating rabbits, 3 different doses (10 mg/kg, 30 mg/kg, and 90 mg/kg) of ponazuril were evaluated. The NOEL for developmental toxicity was found to be 90 mg/kg, whereas the NOEL for maternal toxicity was much lower (30 mg/kg)." - Journal of Exotic Pet Medicine, Vol 17, No 3 (July), 2008: pp 228–229

Thanks to Dr. Harvey, Dr. Krempels, & Dr. Flentke!
If you are writing down any information please read: "Unsafe Medical Abbreviations.
1 mL, mls, or ml (milliliter) = 1 cc or cc³ (cubic centimeter), "≈" = "almost equal to", 1 kg = 2.20462262185 lbs
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[Updated on: 09/1/24 07:00]